New antiepileptic drugs—Discovery, development, and update
نویسندگان
چکیده
منابع مشابه
Antiepileptic drugs in development pipeline: A recent update
Epilepsy is the most common neurological disorder which significantly affects the quality of life and poses a health as well as economic burden on society. Epilepsy affects approximately 70 million people in the world. The present article reviews the scientific rationale, brief pathophysiology of epilepsy and newer antiepileptic drugs which are presently under clinical development. We have sear...
متن کاملDevelopment of new antiepileptic drugs: challenges, incentives, and recent advances.
Despite the introduction of many second-generation antiepileptic drugs (AEDs) in the past 15 years, a third of patients with epilepsy remain refractory to available treatments, and newer and more effective therapies are needed. Although our understanding of the mechanisms of drug resistance is fragmented, novel AED targets have been identified, and models of refractory epilepsy have been develo...
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In a prospective observational study published in the current issue of Neurology®, Shallcross et al. compared cognitive and language skills of children born to women with epilepsy (WWE) exposed in utero to levetiracetam (LEV, n 5 53) or sodium valproate (VPA, n5 44), and control children born to mothers without epilepsy or medication exposure during pregnancy (n5 133). WWE were recruited from t...
متن کاملNew antiepileptic drugs and women
Since 1990, sixteen new antiepileptic drugs (AEDs) have been introduced. Most of these new AEDs have only been insufficiently studied with respect to women-specific aspects such as endogenous sex hormones, hormonal contraception, pregnancy, breastfeeding, or menopause. This is of concern because it has been shown for some of the new AEDs that these factors may have a clinically significant impa...
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The taxanes (paclitaxel and docetaxel) represent an important class of antineoplastic agents that interfere with microtubule function leading to altered mitosis and cellular death. Paclitaxel (Taxol(®)) was originally extracted from a yew tree (Taxus spp., Taxaceae) a small slow-growing evergreen, coniferous tree. Due to the initial scarcity of paclitaxel, docetaxel (Taxotere(®)) a semisyntheti...
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ژورنال
عنوان ژورنال: Neurotherapeutics
سال: 2007
ISSN: 1933-7213,1878-7479
DOI: 10.1016/j.nurt.2006.10.007